Sunday, 5 January 2014

Sedation


“Can’t you just put me to sleep to do that?”


Try to stay awake for this week’s topic…sedation. Insert drum and symbol noise here post awful joke.
There is a lot of confusion over methods of pain and anxiety relief used by dentists. This mainly comes from back in t’ day when regular high street dentists, officially known as General Dental Practitioners or GDP’s happily knocked people out to carry out dental treatment.
In 1998 the General Dental Council acted to construct more stringent standards for the use of general anaesthetic for dental treatment as sadly, several people popped their clogs in the dental chair. It endorsed the need for Conscious Sedation provision rather than the continuing provision of General Anaesthesia as a demand led service i.e. for everyone who came in needing a tooth out, a filling, a check up, would no longer automatically receive general anaesthetic as standard.
Although the publication of the GDC regulations  was followed by a substantial reduction in the use of general anaesthesia for dental treatment, two further deaths occurred outside hospital following general anaesthesia for dental treatment. Following several more rather tedious but nevertheless important reports, a final set of regulations were developed which state that “by 31 December 2001, all general anaesthesia for dental treatment should be administered in a hospital setting with critical care facilities.
This led, positively, to an increase in the use of sedation. Sadly, the dentists of yesteryear – yes even as recently as 2001 – were not so good on the communication front and either through this or through lack of knowledge themselves did not adequately explain to patients the difference between general anaesthetic, aka being knocked out, being put to sleep, and sedation.
For this reason we still on a daily basis see patients booked in on clinics to receive sedation for their dental treatment who either a) are unsuitable for sedation (I will explain further below, these people are usually weeded out at the consultation appointment but some still manage to wiggle through the net) OR b) believe they are going to be asleep i.e. have general anaesthetic for the procedure,
Why does it matter? I hear you ask. Well in some cases you are right. Why some people feel the need to be asleep to have a filling when others will happily have half their face hacked off without even a local anaesthetic is a mystery however our friends at the GDC state “dentists have a duty to provide and patients have a right to expect adequate and appropriate pain and anxiety control”. In some cases, due to general or mental health issues, or in fact the nature of the dental procedure alone, local anaesthetic simply is not enough.

Therefore there are several options ON TOP OF local anaesthetic than can be considered. The reason I slipped onto the old caps lock button is because sedation is not the be all and end all. It helps you relax, stay calm, prevent certain stress-related illnesses from escalating during treatment, it does not however provide complete pain relief and so local anaesthetic – yes the one via the needle – is still vital and patients need to be made aware of this otherwise you will find yourself in front of the not-so-friendly GDC being accused of assault.

How we can help

Here is the wordy bit. In order to eliminate confusion caused by the aforementioned poor communicators, we now refer to sedation as “conscious sedation” purely because you remain fully conscious for the entire time. Yes that’s right, you are not asleep, in a coma, and in fact remain fully in control of your body movements including the very important (if not slightly annoying) gag reflex, ability to open and close the mouth etc.

Here is exactly what I said above but in nice technical terms;
“conscious sedation is a technique in which the use of a drug…produces a state of depression of the central nervous system enabling treatment to be carried out, but during which verbal contact with the patient is maintained throughout the period of sedation. The drugs and techniques used to provide conscious sedation for dental treatment should carry a margin of safety wide enough to render loss of consciousness unlikely.

Delivery of conscious sedation comes in several forms – inhalation i.e. you breathe in the drug, or intravenous i.e. the drug is given directly into the bloodstream.

Inhalation Sedation

The drug you inhale is the same thing they give pregnant women when giving birth – laughing gas known as Nitrous Oxide. This chemical has the added quality over intravenous sedation of providing pain relief when inhaled. The American Academy of Paediatric Dentistry (AAPD) helpfully describe it as a colourless gas with a faint, sweet smell. It is an effective analgesic (pain relieving)/anxiolytic (anxiety relieving) agent causing central nervous system (CNS) depression and euphoria with little effect on the respiratory system. Translation: it makes you calm and happy without compromising any breathing reflexes or causing harm to the lungs or airways which is particularly important in people with things like asthma, where irritation of the airways can cause problems.


Pros
Cons
Quickly excreted from lungs – so effects wear off rapidly
Need for flow of pure oxygen after delivery of nitrous oxide as it leaves the blood stream much quicker than oxygen can replace it. Not really a disadvantage as 100% oxygen feels awesome and is automatically available wherever inhalation sedation is being given
No airway irritation
Feeling of loss of control
Nitrous oxide is absorbed rapidly, allowing for both rapid onset (two to three minutes)
You have to wear a mask in order to breathe the gas, anyone suffering from claustrophobia may struggle with this
It causes minimal impairment of any reflexes, thus protecting the cough reflex however has the added benefit of reducing very strong gag reflexes allowing certain treatment to be carried out that otherwise the patient may not be able to tolerate e.g. impressions
You need to be able to breathe through your nose, therefore if you have trouble with this e.g. broken nose, a cold, then you are unsuitable for this type of sedation
Extremely safe when used correctly
For the same reason as above, if treatment required needs us to be near your top front teeth, the mask gets in the way and so is not suitable
Extremely effective at reducing anxiety/ increasing tolerance to dental procedures particularly long or more difficult treatment.
It does not work alone. That is to say, the drug is not powerful enough used by itself to relieve all anxiety. It requires reassurance and “behavioural management” to be effective.


Who is it suitable for:

1.    Anxious patients. It is important to ascertain the reason for anxiety. As I mentioned above, it is still necessary to have local anaesthetic injections (yes, the dreaded needle) with ALL types of sedation and so while you care less when you under conscious sedation, if the fear of needles is extensive then the patient will be unsuitable for treatment under sedation.
2.    A patient whose gag reflex interferes with dental care;
3.    Patients where good, effective local anaesthesia cannot be achieved e.g. heavily infected teeth, low pain threshold
4.    A cooperative child undergoing a lengthy dental  procedure.
5.    Patients will well controlled diseases that can be worsened by stress e.g. angina, asthma

Contraindications for use of nitrous oxide/oxygen inhalation may include:

1.    some patients with chronic obstructive pulmonary diseases (COPD) – certain tests will be performed before placing a patient on a list for inhalation sedation, and the results of these tests will determine whether or not patients are suitable
2.    severe emotional disturbances. As mentioned above, the inhalation sedation does not work alone in reducing anxiety or making a patient feel like what you are about to do to their teeth is within the realms of something they can tolerate. Certain mental health disorders are too difficult to manage using the techniques of inhalation sedation
3.    drug-related dependencies. This includes alcohol as the metabolism of the drug, i.e. the way it works is affected heavily by certain drugs and alcohol.
4.    first trimester of pregnancy. Ideally we avoid inhalation sedation but it is still preferred over general anaesthetic so it is taken on a case by case basis.
5.    Severe heart disease, again, as with the respiratory problems, the results of pre-op tests will give us an idea of the level of disease and therefore whether sedation is appropriate
6.    Blood problems – Including factor deficiencies e.g. haemophilia, nutrient deficiencies e.g. anaemia
7.    As mentioned before , anything that prevents or makes it difficult for a patient to breathe through their nose which could be as simple as a current or recent cold.  


Now we have gone through all that, which involves enough paperwork to fell a small forest, if you are deemed suitable for sedation there are certain things that you must or must not do.

Oh by the way, this is what it looks like

 



See, even children can do it. You just breathe in through the nose, and out usually through the mouth because it is open for us to do the treatment. It is quite tight fitting and you feel a bit like a horse with a nose bag, but you are being pumped with the wonder that is nitrous oxide, so you couldn’t care less.
Some people would describe the feeling of receiving the sedation as like “being a bit drunk”. As a health professional I of course cannot comment on this but a friend told me a the warm glow after a few glasses of wine comes pretty close to the feeling of sedation.

Dos and Don’ts

  1. Don’t starve but don’t stuff yourself either. Some people say that inhalation sedation makes them feel a bit sick and a full stomach won’t help with this feeling. A light meal a few hours before treatment is perfect.
  2. A responsible adult escort must accompany the patient home from the dental surgery and assume responsibility for the patient’s post-sedation care.
  3. Wherever possible arrangements should be made for the patient and escort to travel home by private car or taxi rather than public transport. Where this is not possible, the escort must be made aware of the added responsibilities of caring for the patient during the journey home.
  4.  No alcohol 24 hours before AND after the sedation.
  5. Take your regular medication as  normal as this will have been factored into the decision of whether you a patient is suitable for sedation and so there is no need to stop if you have been deemed appropriate.


Intravenous Sedation

This involves use of drug called Midazolam, and less frequently Propofol.  This I suppose could be considered as a slightly stronger form of conscious sedation and is often the culprit which causes confusion between sedation and general anaesthetic. The drug/magic potion is given via a cannula in the back of the hand/inside of the elbow which is the same as with general anaesthetic, hence the mix up.


 



Despite the needle only being present for a matter of seconds, a severe needle phobia will also rule out intravenous sedation alone. As with inhalation sedation, local anaesthetic injections will also be required after the sedation agent is given. Usually by the point people are happy for you to take a pneumatic drill to their face but the inserting of the cannula on someone particularly anxious can be very stressful and if this is the case then they are unsuitable for this form of anaesthesia. In some cases, inhalation or oral sedation (a tablet) can be given prior to the insertion of the cannula and this can often be enough to alleviate the patient’s worries about needles enough for sedation to be given.

Because of the drug given for IV sedation, there are a few more contraindications for this type of sedation vs Inhalation.
The same reasons for giving inhalation sedation also apply for IV sedation however a few more can be added, for example, patients suffering from epilepsy or Parkinsons disease would benefit from treatment under IV sedation as the drug given for sedation has strong action against involuntary movements for instance those that occur during an epileptic seizure.

Who IV sedation is NOT suitable for.

1.    Very young or very old patients. The reason for this is that the drug is broken down by the liver, kidneys etc and if these are not functioning at the correct level the patient can have a very unpredictable level of sedation. The same applies for patients with severe liver or kidney disease (including alcoholics who may have a poorly functioning liver without knowing it)
2.    Pregnancy (you literally cannot do ANYTHING fun when pregnant)
3.    Severe hormone issues e.g. thyroid disease, poorly controlled diabetes, adrenal insuffiency treated with steroids

Whilst this does not rule out patients from receiving IV sedation, certain medications amplify the effects of sedation and so the delivery of the drug will need to be modified. The list of drugs is fairly extensive but includes:
1.    Antihistamines (e.g. for allergies including hayfever)
2.    Antihypertensives (blood pressure)
3.    Alcohol
4.    Opioid drugs  – the legal or illegal kind
5.    Anti epileptic drugs – because they often have the same action as midazolam used for sedation
6.    Anti depressants
7.    Obesity. For several reasons.
a.    Finding a vein
b.    Unpredictable metabolism (breaking down and using )of the drug by the body
c.    Difficult monitoring of breathing rate, heart rate etc which is VITAL throughout sedation
d.    Difficulty in treating medical emergencies e.g. if CPR is required
8.    Blood disorders – haemophilia, thalassemia, sickle cell anaemia etc

IV sedation makes you feel a bit more drunk than with inhalation sedation, but again, all within the boundaries of the nice happy warm place before you decide late night karaoke/snogging your boss is a good idea.
The added benefit of IV sedation is that is SOME people it causes loss of memory for the time that the sedation was given. Whilst this is beneficial sometimes because it means the patient may not remember a possibly not so nice bit of dental treatment, it also means that the patient may not remember how well they coped/how calm they felt, and so every time they have sedation, their fears remain the same because it feels like the first time even after 50 attempts. I must stress that whilst this amnesia occurs a lot, it cannot be promised, and some people remember everything.  

The Dos and Don’ts remain relatively the same. No alcohol. Escort is required. However because IV sedation takes much longer to wear off and be completely eradicated from the body, extra care has to be taken for 24 hours. This means no signing of important documents, no cooking (beyond a microwave ready meal), no looking after children, no driving. Therefore, the responsibilities of the escort that a patient chooses are greater than with inhalation sedation.
As with inhalation sedation, starvation is not recommended before IV sedation however we recommend not to eat for 2 hours prior to Midazolam sedation, or 6 hours before use of Propofol.

Again, whilst there seems to be a long list of dos and don’ts in summary. Conscious sedation implies that the patient has:
• Minimally depressed consciousness
• Ability to maintain open airway
• Protective reflexes maintained

• Response to physical and verbal stimulation (European Archives of Paediatric Dentistry)

 

i.e. YOU ARE NOT ASLEEP. NOT EVEN A BIT. NOPE. NOT EVEN DOZING.


Sedation is an extremely useful tool in treating lots of different people for lots of different reasons. For most of us it is given as an option for taking out wisdom teeth because this can often be a more extensive procedure than having a scale and polish so do not be afraid to ask to be referred for it!

Where I borrowed stuff from

General Anaesthesia for Dental Treatment in a Hospital Setting with Critical Care Facilities, Chief Dental Officer, 31 May 2001
GENERAL DENTAL COUNCIL, Maintaining Standards, paragraph 4.8
Scottish Dental Clinical Effectiveness Programme Conscious Sedation in Dentistry Dental Clinical Guidance Second Edition 


1 comment:

  1. Some dentists used abusive sedative for patients in order to get more profits. We also listened to news about patients death during dental surgery because of abusive sedative. The article lists "Dos and Don’ts" and "Who IV sedation is NOT suitable for." Very good.

    Zeta dental blog

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